Biomedical Research Unit, Vall d'Hebron Research Institute, Barcelona, Spain.
Clin Transl Oncol. 2012 Oct;14(10):715-20. doi: 10.1007/s12094-012-0866-3. Epub 2012 Aug 22.
Endometrial cancer (EC) is the most common gynecologic malignancy of the female genital tract and the fourth most common neoplasia in women. In EC, myometrial invasion is considered one of the most important prognostic factors. For this process to occur, epithelial tumor cells need to undergo an epithelial to mesenchymal transition (EMT), either transiently or stably, and to differing degrees. This process has been extensively described in other types of cancer but has been poorly studied in EC. In this review, several features of EMT and the main molecular pathways responsible for triggering this process are investigated in relation to EC. The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation. Pathways including progesterone receptor, TGFβ, ETV5 and microRNAs are deeply related to the EMT process in EC.
子宫内膜癌（EC）是女性生殖道最常见的妇科恶性肿瘤，也是女性第四大常见肿瘤。在 EC 中，肌层浸润被认为是最重要的预后因素之一。为了发生这种过程，上皮肿瘤细胞需要经历上皮间质转化（EMT），无论是短暂的还是稳定的，并且程度不同。这个过程在其他类型的癌症中已经被广泛描述，但在 EC 中研究得很少。在这篇综述中，研究了 EMT 的几个特征和主要的分子途径，这些途径与 EC 有关。已经在 EC 中发现了 EMT 的最常见标志，无论是在 E-钙黏蛋白丢失的水平上，还是在诱导其抑制剂的水平上，以及其他与间充质表型一致的分子改变，如 L1CAM 和 BMI-1 的上调。包括孕激素受体、TGFβ、ETV5 和 microRNAs 在内的途径与 EC 中的 EMT 过程密切相关。
