癌症的微观世界。
The microcosmos of cancer.
机构信息
Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.
出版信息
Nature. 2012 Feb 15;482(7385):347-55. doi: 10.1038/nature10888.
Abstract
The discovery of microRNAs (miRNAs) almost two decades ago established a new paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have been linked to virtually all known physiological and pathological processes, including cancer. In the same way as certain key protein-coding genes, miRNAs can be deregulated in cancer, in which they can function as a group to mark differentiation states or individually as bona fide oncogenes or tumour suppressors. Importantly, miRNA biology can be harnessed experimentally to investigate cancer phenotypes or used therapeutically as a target for drugs or as the drug itself.
摘要
近二十年前 microRNAs（miRNAs）的发现开创了基因调控的新范例。在过去的十年中，这些微小的非编码 RNA 与几乎所有已知的生理和病理过程相关联，包括癌症。与某些关键的蛋白编码基因一样，miRNAs 在癌症中可以失调，它们可以作为一个群体来标记分化状态，或者作为真正的癌基因或肿瘤抑制因子单独发挥作用。重要的是，miRNA 生物学可以被用于实验研究癌症表型，也可以作为药物的靶点进行治疗，或者本身就是药物。
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1
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Cancer Cell. 2011 Aug 16;20(2):187-99. doi: 10.1016/j.ccr.2011.06.016.
2
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization.miR-200s 通过直接靶向 Sec23a 影响癌细胞分泌组并促进转移定植。
Nat Med. 2011 Aug 7;17(9):1101-8. doi: 10.1038/nm.2401.
3
A resource of vectors and ES cells for targeted deletion of microRNAs in mice.用于在小鼠中靶向敲除 microRNAs 的载体和 ES 细胞资源。
Nat Biotechnol. 2011 Aug 7;29(9):840-5. doi: 10.1038/nbt.1929.
4
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.RNAi 筛选鉴定 Brd4 为急性髓系白血病的治疗靶点。
Nature. 2011 Aug 3;478(7370):524-8. doi: 10.1038/nature10334.
5
Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina.海绵转基因小鼠模型揭示了 microRNA-183（miR-183）/96/182 簇在视网膜有丝分裂后光感受器中的重要作用。
J Biol Chem. 2011 Sep 9;286(36):31749-60. doi: 10.1074/jbc.M111.259028. Epub 2011 Jul 15.
6
p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.p53 通过靶向 ZEB1 和 ZEB2 的 microRNAs 调节上皮-间充质转化。
J Exp Med. 2011 May 9;208(5):875-83. doi: 10.1084/jem.20110235. Epub 2011 Apr 25.
7
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Blood. 2011 Jun 9;117(23):6255-66. doi: 10.1182/blood-2010-10-315432. Epub 2011 Apr 8.
8
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9
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