Dept of Pathology and Laboratory Medicine, 6 Founders, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.
Am J Clin Pathol. 2012 Sep;138(3):382-9. doi: 10.1309/AJCPUXAP6P2GVBTI.
Urothelial carcinomas arising from the upper urinary tract (renal pelvis and ureter) are rare and few molecular genetic studies of these tumors have been conducted to date. We investigated hyperploidy at chromosomes 3, 7, and 17 using a multitarget fluorescence in situ hybridization system to identify genetic alterations in patients with urothelial carcinomas of the upper urinary tract. Chromosomal aberrations are seen most frequently in the high-grade tumors. A highly significant relationship was found between an increase in the percentage of hyperdiploidy and high grade for each chromosome (chromosome 3, P = 6 × 10(-4); chromosome 7, P = 2 × 10(-4); chromosome 17, P = 6 × 10(-5)). To determine whether these associations were independent for each chromosome, the correlation between percentage of hyperdiploidy for each pair of chromosomes was examined. In each case, the correlation was highly significant (R = 0.89-0.91). No statistically significant association was found between percentage of hyperdiploidy and tumor stage for any chromosome.
上尿路（肾盂和输尿管）来源的尿路上皮癌较为罕见，迄今为止，对这些肿瘤的分子遗传学研究较少。我们使用多靶点荧光原位杂交系统检测了染色体 3、7 和 17 的三倍体，以鉴定上尿路上皮癌患者的遗传改变。染色体异常在高级别肿瘤中最常见。在每个染色体中，高倍体百分比的增加与高级别之间存在高度显著的关系（染色体 3，P=6×10(-4)；染色体 7，P=2×10(-4)；染色体 17，P=6×10(-5)）。为了确定这些关联是否对每个染色体都是独立的，我们检查了每对染色体的高倍体百分比之间的相关性。在每种情况下，相关性都非常显著（R=0.89-0.91）。任何染色体的高倍体百分比与肿瘤分期之间均无统计学显著关联。
