Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Center for Biomedical Research, University of Granada, Granada, Spain.
Diabetes Care. 2012 Nov;35(11):2373-6. doi: 10.2337/dc12-0614. Epub 2012 Aug 21.
Obesity is associated with a state of chronic low-grade inflammation. Myeloperoxidase (MPO) plays an important role in the initiation and progression of acute and chronic inflammatory diseases, such as cardiovascular disease (CVD). The objectives of the current study were to evaluate plasma MPO levels in prepubertal obese children and to determine whether MPO could be an early biomarker of inflammation and CVD risk.
In a prospective multicenter case-control study paired by age and sex of 446 Caucasian prepubertal children ages 6-12 years, 223 normal-weight and 223 obese children were recruited. Blood pressure, waist circumference, weight, and height were measured. In addition to MPO, glucose, insulin, metabolic lipid parameters, oxidized low-density lipoproteins, adiponectin, leptin, resistin, C-reactive protein (CRP), interleukin 6, tumor necrosis factor α, matrix metalloproteinase-9 (MMP-9), and plasminogen activator inhibitor 1 were determined.
We found that MPO was elevated in prepubertal obese children and that this enzyme was associated with such proinflammatory and cardiovascular risk biomarkers as CRP, MMP-9, and resistin. Insulin resistance calculated by the homeostatic assessment model was the best predictor of MPO.
MPO is an early biomarker of inflammation associated with CVD risk in obese children at the prepubertal age.
肥胖与慢性低度炎症状态有关。髓过氧化物酶（MPO）在急性和慢性炎症性疾病（如心血管疾病（CVD））的发生和进展中起着重要作用。本研究的目的是评估青春期前肥胖儿童的血浆 MPO 水平，并确定 MPO 是否可以作为炎症和 CVD 风险的早期生物标志物。
在一项前瞻性、多中心病例对照研究中，对 446 名 6-12 岁的白种人青春期前儿童按年龄和性别进行配对，其中 223 名体重正常，223 名肥胖。测量血压、腰围、体重和身高。除 MPO 外，还测定了葡萄糖、胰岛素、代谢脂质参数、氧化型低密度脂蛋白、脂联素、瘦素、抵抗素、C 反应蛋白（CRP）、白细胞介素 6、肿瘤坏死因子-α、基质金属蛋白酶-9（MMP-9）和纤溶酶原激活物抑制剂 1。
我们发现青春期前肥胖儿童的 MPO 升高，这种酶与 CRP、MMP-9 和抵抗素等促炎和心血管风险生物标志物相关。稳态评估模型计算的胰岛素抵抗是 MPO 的最佳预测因子。
MPO 是青春期前肥胖儿童与 CVD 风险相关的炎症的早期生物标志物。
