通过RNA定位实现翻译的空间调控。
Spatial regulation of translation through RNA localization.
作者信息
Gonsalvez Graydon B, Long Roy M
出版信息
F1000 Biol Rep. 2012;4:16. doi: 10.3410/B4-16. Epub 2012 Aug 1.
Abstract
RNA localization is a mechanism to post-transcriptionally regulate gene expression. Eukaryotic organisms ranging from fungi to mammals localize mRNAs to spatially restrict synthesis of specific proteins to distinct regions of the cytoplasm. In this review, we provide a general summary of RNA localization pathways in Saccharomyces cerevisiae, Xenopus, Drosophila and mammalian neurons.
摘要
RNA定位是一种转录后调控基因表达的机制。从真菌到哺乳动物的真核生物将mRNA定位，以便在空间上把特定蛋白质的合成限制在细胞质的不同区域。在这篇综述中，我们对酿酒酵母、非洲爪蟾、果蝇和哺乳动物神经元中的RNA定位途径进行了概述。
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