IRHS, Agrocampus-Ouest, INRA, Université d'Angers, SFR 4207 QUASAV, F-49045 Angers, France.
Int J Mol Sci. 2018 Jan 30;19(2):410. doi: 10.3390/ijms19020410.
Post-transcriptional regulation of gene expression plays a crucial role in many processes. In cells, it is mediated by diverse RNA-binding proteins. These proteins can influence mRNA stability, translation, and localization. The PUF protein family (Pumilio and FBF) is composed of RNA-binding proteins highly conserved among most eukaryotic organisms. Previous investigations indicated that they could be involved in many processes by binding corresponding motifs in the 3'UTR or by interacting with other proteins. To date, most of the investigations on PUF proteins have been focused on , , and , while only a few have been conducted on . The present article provides an overview of the PUF protein family. It addresses their RNA-binding motifs, biological functions, and post-transcriptional control mechanisms in , , , and . These items of knowledge open onto new investigations into the relevance of PUF proteins in specific plant developmental processes.
基因表达的转录后调控在许多过程中起着至关重要的作用。在细胞中，它是由多种 RNA 结合蛋白介导的。这些蛋白质可以影响 mRNA 的稳定性、翻译和定位。PUF 蛋白家族（Pumilio 和 FBF）由 RNA 结合蛋白组成，在大多数真核生物中高度保守。先前的研究表明，它们可以通过结合 3'UTR 中的相应基序或与其他蛋白质相互作用来参与许多过程。迄今为止，对 PUF 蛋白的研究大多集中在、、和上，而只有少数集中在、、和上。本文综述了 PUF 蛋白家族。它讨论了它们在、、和中的 RNA 结合基序、生物学功能和转录后调控机制。这些知识为研究 PUF 蛋白在特定植物发育过程中的相关性提供了新的依据。
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