Rizvi Imran, Ansari Noor Alam, Beg Mujahid, Shamim Md Dilawez
Department of Medicine, Jawaharlal Nehru Medical College, Aligarh, India.
N Am J Med Sci. 2012 Aug;4(8):369-72. doi: 10.4103/1947-2714.99523.
Hypoparathyroidism can present with neurological complaints like seizures, parasthesias, depression, psychosis, extrapyramidal manifestations and features of raised intracranial pressure. Hypoparathyroidism and pseudohypoparathyroidism are the most common causes of pathological basal ganglia calcification. A 50 year male presented with generalized seizures and extrapyramidal features like tremors and rigidity. Investigations revealed that he had hypocalcemia, hyperphosphatemia and very low PTH levels, CT scan of head showed calcification of bilateral basal ganglia, cerebellum and subcortical white matter of frontal and parietal lobes. He showed remarkable recovery on restoration of normal serum calcium levels. Hypoparathyroidism should be kept in the differential diagnosis of patients presenting with seizures and extrapyramidal features.
甲状旁腺功能减退可表现为癫痫发作、感觉异常、抑郁、精神病、锥体外系表现及颅内压升高的症状等神经方面的主诉。甲状旁腺功能减退和假性甲状旁腺功能减退是病理性基底节钙化最常见的原因。一名50岁男性出现全身性癫痫发作及震颤和强直等锥体外系症状。检查发现他有低钙血症、高磷血症且甲状旁腺激素水平极低，头部CT扫描显示双侧基底节、小脑以及额叶和顶叶皮质下白质钙化。在血清钙水平恢复正常后，他的症状有显著改善。对于出现癫痫发作和锥体外系症状的患者，鉴别诊断时应考虑甲状旁腺功能减退。
