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SURTAVI 模型:严重主动脉瓣狭窄患者实用风险分层的建议。

The SURTAVI model: proposal for a pragmatic risk stratification for patients with severe aortic stenosis.

机构信息

Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.

出版信息

EuroIntervention. 2012 Jun 20;8(2):258-66. doi: 10.4244/eijv8i2a40.

Abstract

Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical aortic valve replacement (SAVR) for patients with symptomatic severe aortic stenosis (AS) and a high operative risk. Risk stratification plays a decisive role in the optimal selection of therapeutic strategies for AS patients. The accuracy of contemporary surgical risk algorithms for AS patients has spurred considerable debate especially in the higher risk patient population. Future trials will explore TAVI in patients at intermediate operative risk. During the design of the SURgical replacement and Transcatheter Aortic Valve Implantation (SURTAVI) trial, a novel concept of risk stratification was proposed based upon age in combination with a fixed number of predefined risk factors, which are relatively prevalent, easy to capture and with a reasonable impact on operative mortality. Retrospective application of this algorithm to a contemporary academic practice dealing with clinically significant AS patients allocates about one-fourth of these patients as being at intermediate operative risk. Further testing is required for validation of this new paradigm in risk stratification. Finally, the Heart Team, consisting of at least an interventional cardiologist and cardiothoracic surgeon, should have the decisive role in determining whether a patient could be treated with TAVI or SAVR.

摘要

经导管主动脉瓣植入术(TAVI)是一种有创性较小的方法,可替代手术主动脉瓣置换术(SAVR),用于有症状的严重主动脉瓣狭窄(AS)和高手术风险的患者。风险分层在 AS 患者最佳治疗策略的选择中起着决定性的作用。当代外科风险算法在 AS 患者中的准确性引起了相当大的争议,尤其是在高风险患者群体中。未来的试验将探讨 TAVI 在中手术风险患者中的应用。在 SURgical replacement 和 Transcatheter Aortic Valve Implantation(SURTAVI)试验的设计过程中,提出了一种基于年龄结合固定数量的预设风险因素的新型风险分层概念,这些风险因素相对常见、易于捕捉,并且对手术死亡率有合理的影响。将该算法回顾性地应用于处理具有临床意义的 AS 患者的当代学术实践中,将这些患者中的约四分之一分配为中手术风险。需要进一步的测试来验证这种新的风险分层模式。最后,由至少一名介入心脏病专家和心胸外科医生组成的心脏团队,应该在决定患者是否可以接受 TAVI 或 SAVR 治疗方面发挥决定性作用。

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