Grigor'ev I P, Sukhorukova E G, Kolos E A, Korzhevskiĭ D E
Morfologiia. 2012;141(2):65-7.
The distribution of tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, was studied immunocytochemically in the neurons of substantia nigra in the human brain (n=7), and localization of neuromelanin in these cells was determined. The evidence indicating the existence of three types of neurons in substantia nigra was obtained, including the neurons containing both TH and neuromelanin, neurons containing only neuromelanin, and neurons expressing neither TH, nor neuromelanin. Presence of a population of neuromelanin-containing neurons lacking TH (which make up 7-30% of the cells) is discussed considering the participation of catecholamines and TH in neuromelanin synthesis.
采用免疫细胞化学方法研究了人脑黑质神经元中儿茶酚胺合成关键酶酪氨酸羟化酶（TH）的分布，并确定了这些细胞中神经黑色素的定位。获得了表明黑质中存在三种类型神经元的证据，包括同时含有TH和神经黑色素的神经元、仅含有神经黑色素的神经元以及既不表达TH也不表达神经黑色素的神经元。考虑到儿茶酚胺和TH在神经黑色素合成中的作用，讨论了缺乏TH的含神经黑色素神经元群体（占细胞总数的7 - 30%）的存在情况。
