Zhang Cang-lin, Zhou Hong-ning, Wang Jian, Liu Hui
Department of Pathogen Biology, The Second Military Medical University, Shanghai 200025, China.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2012 Feb 29;30(1):41-4.
To assess the in vitro sensitivity of Plasmodium falciparum to chloroquine, piperaquine and pyronaridine in China-Myanmar border area.
Fifty-one blood specimens of P. falciparum isolates were collected from Laza City of Myanmar during September to December in 2009, and the sensitivity of the parasites to the drugs was detected by Rieckmann's in vitro microtest.
Among the 42 blood samples with valid results of sensitivity test, the resistance rate to chloroquine, piperaquine and pyronaridine was 95.2%, 7.1%, and 54.8%, with a corresponding 50% inhibition dose (IDn) of 320.5, 128.2, and 96.0 nmol/L, respectively. Pyronaridine-resistant P. falciparum exhibited some degree of cross-resistance to chloroquine [91.3%(21/23)] and piperaquine [13.0% (3/23)], and chloroquine-resistant P. falciparum showed cross-resistance to piperaquine [7.5%(3/40)] and pyronaridine [52.5%(21/40)]. High level of cross-resistance was present to chloroquine (100%) and pyronaridine (100%) in piperaquine resistant P. falciparum.
In Laza City, P. falciparum shows high resistance to chloroquine, half isolates are resistant to pyronaridine, and most isolates are still sensitive to piperaquine.
评估中国-缅甸边境地区恶性疟原虫对氯喹、哌喹和咯萘啶的体外敏感性。
于2009年9月至12月从缅甸腊戍市采集51份恶性疟原虫分离株血液标本，采用里德曼体外微量试验检测疟原虫对药物的敏感性。
在42份敏感性试验结果有效的血样中，对氯喹、哌喹和咯萘啶的耐药率分别为95.2%、7.1%和54.8%，相应的半数抑制剂量（ID50）分别为320.5、128.2和96.0 nmol/L。耐咯萘啶的恶性疟原虫对氯喹[91.3%（21/23）]和哌喹[13.0%（3/23）]表现出一定程度的交叉耐药，耐氯喹的恶性疟原虫对哌喹[7.5%（3/40）]和咯萘啶[52.5%（21/40）]表现出交叉耐药。耐哌喹的恶性疟原虫对氯喹（100%）和咯萘啶（100%）存在高水平交叉耐药。
在腊戍市，恶性疟原虫对氯喹高度耐药，半数分离株对咯萘啶耐药，多数分离株对哌喹仍敏感。
Zotero 插件