Yang H, Liu D, Dong Y, Yang P, Liu R, Zhang B, Zhang C
Institute of Malaria Prevention and Treatment of Yunnan Province, Simao.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1995;13(2):111-3.
The sensitivity of P. falciparum to chloroquine (CHL), piperaquine (PIP), artesunate (ATS), dihydroartemisinine (DAT), artemether (ATM), arteether (ATE) and pyronaridine (PRN) were assayed by in vitro microtechnique in China-Laos border in 1992. The resistance rates of isolates from the south of Yunnan of China in the border were 97.0%, 96.4%, 12.5%, 16.0%, 6.3% and 34.5%, respectively; ID50 were 119.0, 320.0, 7.2, 5.4, 295.0, 74.4 and 31.9 nmol/L, ID95 were 625.0, 2426.0, 42.2, 36.6, 767.0, 371.1 and 325.2 nmol/L. The resistance rates of isolates from the north border of Laos were in order 9/10, 8/10, 1/5 to CHL, PIP, PRN, ID50 were 114.0, 166.9, 16.4 nmol/L, ID95 were 570.0, 631.1 and 107.7 nmol/L. All the isolates from Laos were sensitive to ATS, DAT, ATM and ATE. ID50 were 5.0, 4.4, 91.6 and 56.7 nmol/L, ID95 were 23.4, 11.1, 3276.1 and 223.9 nmol/L, respectively. The results indicate that P. falciparum in the border was highly resistant to CHL and PIP, while most of the isolates were susceptible to the other 5 of the above-mentioned drugs. A comparison between the isolates from China and Laos showed that there was no significant difference in resistance degree to CHL but the sensitivity of isolates from China to other 6 drugs was lower than those from Laos.
1992年在中国-老挝边境采用体外微量技术测定了恶性疟原虫对氯喹（CHL）、哌喹（PIP）、青蒿琥酯（ATS）、双氢青蒿素（DAT）、蒿甲醚（ATM）、蒿乙醚（ATE）和咯萘啶（PRN）的敏感性。中国云南边境地区南部分离株的耐药率分别为97.0%、96.4%、12.5%、16.0%、6.3%和34.5%；半数抑制浓度（ID50）分别为119.0、320.0、7.2、5.4、295.0、74.4和31.9纳摩尔/升，95%抑制浓度（ID95）分别为625.0、2426.0、42.2、36.6、767.0、371.1和325.2纳摩尔/升。老挝边境北部分离株对氯喹、哌喹、咯萘啶的耐药率依次为9/10、8/10、1/5，ID50分别为114.0、166.9、16.4纳摩尔/升，ID95分别为570.0、631.1和107.7纳摩尔/升。老挝所有分离株对青蒿琥酯、双氢青蒿素、蒿甲醚和蒿乙醚均敏感。ID50分别为5.0、4.4、91.6和56.7纳摩尔/升，ID95分别为23.4、11.1、3276.1和223.9纳摩尔/升。结果表明，边境地区的恶性疟原虫对氯喹和哌喹高度耐药，而大多数分离株对上述其他5种药物敏感。中国和老挝分离株之间的比较表明，对氯喹的耐药程度无显著差异，但中国分离株对其他6种药物的敏感性低于老挝分离株。
