Ragon Institute of MGH, MIT and Harvard, Building 149, 13th Street, 6th Floor, Boston, MA 02129, USA.
Expert Rev Vaccines. 2012 Jul;11(7):775-7. doi: 10.1586/erv.12.48.
The recent Keystone Symposia meeting on HIV Vaccines was held on 21-26 March 2012 in Keystone (CO, USA) back-to-back with the Viral Immunity meeting, creating synergy between the two areas of research. In this short report of the meeting, the authors will highlight three areas of interest that emerged from the two meetings: the recently emerging role of NK cells in modulating dendritic cell function, new data on the importance of dendritic cell antigen processing on priming of adaptive immunity and intriguing data suggesting that narrow targeting of very few protective epitopes restricted by a single MHC class I allele might be sufficient to mediate control of otherwise highly pathogenic SIV infection.
最近的 HIV 疫苗金标研讨会于 2012 年 3 月 21 日至 26 日在美国科罗拉多州基斯通（Keystone）与病毒免疫研讨会背靠背举行，这两个研究领域之间形成了协同作用。在本次会议的简短报告中，作者将重点介绍这两个会议中出现的三个感兴趣的领域：NK 细胞在调节树突状细胞功能方面的新作用、树突状细胞抗原加工对适应性免疫启动重要性的新数据，以及有趣的数据表明，由单个 MHC Ⅰ类等位基因限制的极少数保护性表位的精确靶向可能足以介导对高度致病性 SIV 感染的控制。
