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GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4+ T cells following smallpox vaccination.GM-CSF 的产生使得鉴定人类 CD4+ T 细胞识别的免疫优势抗原成为可能，这些抗原是在接种天花疫苗后产生的。
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2
Use and implications of the harmonic mean model on mixtures for basic research and drug discovery.用于基础研究和药物发现的混合物调和均值模型的使用和意义。
ACS Comb Sci. 2011 May 9;13(3):337-44. doi: 10.1021/co100065a. Epub 2011 Mar 11.
3
Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.2009年药物发现与化学生物学化学文库综合调查
J Comb Chem. 2010 Nov 8;12(6):765-806. doi: 10.1021/cc100128w. Epub 2010 Oct 5.
4
Positional scanning peptide libraries for kinase substrate specificity determinations: straightforward and reproducible synthesis using pentafluorophenyl esters.用于激酶底物特异性测定的位置扫描肽库：使用五氟苯基酯进行直接且可重复的合成。
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5
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AAPS J. 2010 Sep;12(3):318-29. doi: 10.1208/s12248-010-9191-3. Epub 2010 Apr 27.
6
Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.基于混合物的合成组合文库的使用策略：支架排序、体内直接测试以及通过计算方法进行增强的去卷积。
J Comb Chem. 2008 Jan-Feb;10(1):3-19. doi: 10.1021/cc7001205. Epub 2007 Dec 8.
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Parallel solid-phase synthesis of disubstituted 1,6-piperazine-2-ones.二取代1,6-哌嗪-2-酮的平行固相合成
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一种新型等速比测定方法及其在两个新定位扫描文库合成中的应用。

A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.

机构信息

Torrey Pines Institute for Molecular Studies , 11350 SW Village Parkway, Port St. Lucie, Florida 34987, United States.

出版信息

ACS Comb Sci. 2012 Sep 10;14(9):503-12. doi: 10.1021/co300060s. Epub 2012 Aug 28.

DOI:10.1021/co300060s
PMID:22913403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3825827/
Abstract

A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.

摘要

本文提出了一种用于直接评估混合物中各化合物等摩尔比的新方法。我们将该方法应用于计算树脂结合的肽片段的胺端与磺酰氯之间反应的等动力学比，以产生等摩尔比的磺酰胺混合物。讨论了这项研究的结果以及该方法在合成两个新的位置扫描合成组合文库 (PS-SCL) 中的应用。