一种新型等速比测定方法及其在两个新定位扫描文库合成中的应用。
A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.
机构信息
Torrey Pines Institute for Molecular Studies , 11350 SW Village Parkway, Port St. Lucie, Florida 34987, United States.
出版信息
ACS Comb Sci. 2012 Sep 10;14(9):503-12. doi: 10.1021/co300060s. Epub 2012 Aug 28.
Abstract
A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.
摘要
本文提出了一种用于直接评估混合物中各化合物等摩尔比的新方法。我们将该方法应用于计算树脂结合的肽片段的胺端与磺酰氯之间反应的等动力学比，以产生等摩尔比的磺酰胺混合物。讨论了这项研究的结果以及该方法在合成两个新的位置扫描合成组合文库 (PS-SCL) 中的应用。
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