Department of Molecular Immunology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
Allergy. 2012 Oct;67(10):1203-14. doi: 10.1111/all.12004. Epub 2012 Aug 23.
Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18, and is considered to be important for host defense against nematodes by inducing Th2 cytokine production via the IL-33 receptor. IL-33 receptor is a heterodimer of IL-1 receptor-like 1 (IL-1RL1; also called ST2, T1, Der4, and fit-1) and IL-1 receptor accessory protein (IL-1RAcP). On the other hand, excessive and/or inappropriate production of IL-33 is considered to be involved in the development of various disorders, such as allergic and autoimmune diseases. Unlike IL-1β and IL-18, IL-33 does not seem to be secreted through the activation of inflammasomes in events such as apoptosis. However, IL-33 is localized in the nucleus of cells and is released during tissue injury associated with necrosis. This suggests that it acts as an alarmin, like IL-1α and high-mobility group box chromosomal protein-1 (HMGB-1). This review summarizes current knowledge regarding the roles of IL-33 in the functions of various cell types and the pathogenesis of allergy.
白细胞介素-33（IL-33）是白细胞介素-1 细胞因子家族的一员，包括白细胞介素-1 和白细胞介素-18，被认为通过诱导 IL-33 受体产生 Th2 细胞因子在宿主防御线虫方面很重要。IL-33 受体是白细胞介素-1 受体样 1（IL-1RL1；也称为 ST2、T1、Der4 和 fit-1）和白细胞介素-1 受体辅助蛋白（IL-1RAcP）的异二聚体。另一方面，IL-33 的过度和/或不适当产生被认为与各种疾病的发展有关，如过敏和自身免疫性疾病。与白细胞介素-1β 和白细胞介素-18 不同，白细胞介素-33 似乎不是通过细胞凋亡等事件中炎性体的激活而分泌的。然而，白细胞介素-33 位于细胞核中，并在与坏死相关的组织损伤期间释放。这表明它像白细胞介素-1α 和高迁移率族蛋白 B1（HMGB-1）一样，充当警报素。这篇综述总结了目前关于白细胞介素-33 在各种细胞类型功能和过敏发病机制中的作用的知识。
