Upper Airway Research Laboratory, Department of Oto-Rhino-Laryngology, Ghent University, Ghent, Belgium.
Allergy. 2012 Oct;67(10):1193-202. doi: 10.1111/j.1398-9995.2012.02880.x. Epub 2012 Aug 23.
Airway diseases such as chronic rhinosinusitis, asthma, and chronic obstructive pulmonary disorder are characterized by inflammation and remodeling. Among inflammatory and extracellular matrix regulatory cytokines, transforming growth factor-beta (TGF-β) stands central, as it possesses both important immunomodulatory and fibrogenic activities, and should be considered a key for understanding inflammation and remodeling processes. This review will briefly summarize the recent findings on the role of TGF-β1, from the view points of inflammation and remodeling, and discuss the role of TGF-β in the upper and lower airway diseases. This may reveal new perspectives in the understanding of airway inflammation and remodeling processes and may open innovative treatment strategies for the regulation of TGF-β1.
气道疾病，如慢性鼻-鼻窦炎、哮喘和慢性阻塞性肺疾病，其特征为炎症和重塑。在炎症和细胞外基质调节细胞因子中，转化生长因子-β（TGF-β）处于核心地位，因为它具有重要的免疫调节和纤维生成活性，应被视为理解炎症和重塑过程的关键。这篇综述将简要总结 TGF-β1 的最新研究结果，从炎症和重塑的角度讨论 TGF-β1 在上下气道疾病中的作用。这可能揭示气道炎症和重塑过程的新视角，并为 TGF-β1 的调节提供创新的治疗策略。
