Studnicka J
Ocní Klinika FN a LF UK, Hradec Králove.
Cesk Slov Oftalmol. 2012 May;68(2):61-3.
The article summarizes data from the literature about new possibilities of the diabetic macular edema treatment. Comparing intravitreal application of triamcinolone and laser photocoagulation, the better effect of the laser treatment with its lower side effects was proven. In combined treatment of triamcinolone and laser photocoagulation comparing with the laser monotherapy, no better effect of the combined therapy was proven. The intravitreal implant releasing fluocinolone acetonide significantly improved the best-corrected visual acuity (BCVA), but caused cataract progression and elevation of the intraocular pressure. Intravitreal application of ranibizumab significantly improved BCVA in the monotherapy, and in the combination with the retinal laser photocoagulation did as well. Intravitreal application of bevacizumab significantly improved BCVA, but its use is off-label only. Aflibercept is in the final stage of clinical trails.
本文总结了文献中有关糖尿病性黄斑水肿治疗新方法的数据。比较曲安奈德玻璃体内注射和激光光凝治疗，结果证明激光治疗效果更好且副作用更小。与单纯激光治疗相比，曲安奈德联合激光光凝治疗未显示出更好的效果。玻璃体内植入氟轻松醋酸酯可显著改善最佳矫正视力（BCVA），但会导致白内障进展和眼压升高。雷珠单抗玻璃体内注射在单药治疗中可显著改善BCVA，与视网膜激光光凝联合使用时效果同样显著。贝伐单抗玻璃体内注射可显著改善BCVA，但仅为非适应证用药。阿柏西普正处于临床试验的最后阶段。
