Yamashita H, Noguchi S, Murakami N, Kato R, Adachi M, Inoue S, Kato S, Nakayama I
Department of Pathology, Medical College of Oita, Japan.
Acta Pathol Jpn. 1990 Oct;40(10):705-12. doi: 10.1111/j.1440-1827.1990.tb01534.x.
Effects of dietary iodine on the induction of thyroid carcinoma using N-nitrosobis(2-hydroxypropyl)amine (BHP) were studied. Male Wistar rats were fed with an iodine-adequate diet (IAD group), an iodine-rich diet (IRD group) and an iodine-deficient diet (IDD group), respectively, until the time of sacrifice. From the 2nd experimental month, animals were injected with BHP once a week for 10 weeks. In the IAD and IRD groups, benign nodules and papillary carcinoma were found. The incidence of rats with benign nodules was 100% in both groups and animals with papillary carcinoma in the IAD and IRD groups comprised 33% and 29%, respectively. The area of the thyroid gland occupied by nodular lesions was much narrower in the IRD group than in the IAD group. In the IDD group, the thyroid showed marked enlargement due to multiple nodular proliferation of follicle cells. The incidence of rats with carcinoma was 100%, and not only papillary but also follicular carcinoma and one pulmonary metastasis were found. As the iodine content of the diet decreased, the nodular lesions increased in width and number, and the incidence of carcinoma in rats became higher. These effects of dietary iodine are probably related to the goitrogenic and/or promoting effects of TSH.
研究了膳食碘对使用N-亚硝基双（2-羟丙基）胺（BHP）诱导甲状腺癌的影响。分别给雄性Wistar大鼠喂食碘充足饮食（IAD组）、高碘饮食（IRD组）和缺碘饮食（IDD组），直至处死。从实验第2个月起，动物每周注射一次BHP，共注射10周。在IAD组和IRD组中，发现了良性结节和乳头状癌。两组中出现良性结节的大鼠发生率均为100%，IAD组和IRD组中出现乳头状癌的动物分别占33%和29%。IRD组中结节性病变所占甲状腺面积比IAD组窄得多。在IDD组中，由于滤泡细胞的多个结节性增生，甲状腺显著肿大。出现癌的大鼠发生率为100%，不仅发现了乳头状癌，还发现了滤泡癌和一例肺转移。随着饮食中碘含量的降低，结节性病变的宽度和数量增加，大鼠的癌发生率升高。膳食碘的这些作用可能与促甲状腺激素的致甲状腺肿和/或促进作用有关。
