Kato S, Yamashita H, Nakayama I
First Department of Pathology, Medical College of Oita, Japan.
Acta Pathol Jpn. 1990 Jan;40(1):1-8. doi: 10.1111/j.1440-1827.1990.tb01522.x.
Nodular lesions induced by N-nitrosobis (2-hydroxypropyl) amine (BHP) and phenobarbital (Pb) in F344 rat thyroid were histologically divided into 2 categories, benign lesions and carcinoma. Benign lesions were subclassified into 3 types mainly based on histological characteristics and localization of peroxidase (PO). The type 1 lesion showed localization of PO almost identical with that of the group 1 rat thyroid. Type 2 was characterized by an intense reaction product of PO in the cytoplasm but a weak one on the surface of the microvilli, and type 3 exhibited localization of PO opposite to that of type 2. Carcinoma proliferated in papillary, follicular and poorly differentiated patterns and developed as de novo carcinoma with the highest incidence, although a considerable number of carcinomas coexisted with benign type 3 lesions. A majority of these carcinomas lacked the reaction product for PO. These results suggest that benign nodular lesions, especially types 2 and 3, show hyperactivity of PO synthesis reflecting their response to excessively secreted TSH, whereas carcinoma is autonomous, because of marked inhibition of PO synthesis even in the presence of TSH hypersecretion.
N-亚硝基双（2-羟丙基）胺（BHP）和苯巴比妥（Pb）诱导的F344大鼠甲状腺结节性病变在组织学上分为2类，即良性病变和癌。良性病变主要根据组织学特征和过氧化物酶（PO）的定位再细分为3型。1型病变的PO定位与1组大鼠甲状腺几乎相同。2型的特征是PO在细胞质中有强烈反应产物，但在微绒毛表面反应较弱，3型的PO定位与2型相反。癌以乳头状、滤泡状和低分化模式增殖，以新发癌的发生率最高，尽管相当数量的癌与良性3型病变共存。这些癌大多数缺乏PO反应产物。这些结果表明，良性结节性病变，尤其是2型和3型，显示出PO合成的亢进，反映了它们对过度分泌的促甲状腺激素（TSH）的反应，而癌是自主性的，因为即使在TSH分泌过多的情况下，PO合成也受到明显抑制。
