MAPK1/3 通路对于 G2019S LRRK2 突变体成纤维细胞中观察到的自噬失调是必不可少的。
The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts.
机构信息
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y T.O., Universidad de Extremadura, Cáceres, Spain.
出版信息
Autophagy. 2012 Oct;8(10):1537-9. doi: 10.4161/auto.21270. Epub 2012 Aug 23.
Abstract
The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LRRK2) gene is related to PD and its implication in autophagy regulation has been described. Our recent work shows that the presence of the G2019S LRRK2 mutation, one of the most prevalent in LRRK2, is accompanied by a deregulation of autophagy basal levels dependent on the MAPK1/3 (ERK2/1) pathway.
摘要
自噬失调与细胞死亡过程之间的联系可能在几种神经退行性疾病的发展中至关重要，如帕金森病（PD）。然而，PD 患者中这种降解过程失调的分子机制尚不清楚。富含亮氨酸重复激酶 2（LRRK2）基因与 PD 有关，其在自噬调节中的作用已被描述。我们最近的工作表明，最常见的 LRRK2 突变之一 G2019S LRRK2 的存在伴随着自噬基础水平的失调，这依赖于 MAPK1/3（ERK2/1）通路。
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