合成一种用于活细胞成像的荧光标记唾液酸类似物。
Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging.
机构信息
RIKEN Advanced Science Institute, Wako, Saitama 351-0198, Japan.
出版信息
Chem Commun (Camb). 2012 Oct 9;48(78):9744-6. doi: 10.1039/c2cc34605b.
PMID:22914432
Abstract
A cytidine 5'-monophosphate (CMP)-sialic acid analogue carrying a fluorescent reporter group, an inhibitor of sialyltransferase, was synthesised in order to investigate glycan synthesis events in cells. The compound was found to be a substrate of a CMP-sialic acid transporter, and specific Golgi vesicles were visualised in the cells.
摘要
为了研究细胞中的糖基合成事件，合成了一种带有荧光报告基团的胞苷 5'-单磷酸（CMP）-唾液酸类似物，它是唾液酸转移酶的抑制剂。该化合物被发现是 CMP-唾液酸转运体的底物，并且在细胞中观察到了特定的高尔基小泡。
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