糖尿病肾病不同阶段患者的平均血小板体积及相关因素：一项初步研究
Mean platelet volume and related factors in patients at different stages of diabetic nephropathy: a preliminary study.
作者信息
Turgutalp Kenan, Özhan Onur, Akbay Esen, Tombak Anil, Tiftik Naci, Ozcan Turkay, Yilmaz Sercan, Helvaci Ilter, Kiykim Ahmet
机构信息
1Division of Nephrology, Department of Internal Medicine, School of Medicine, Mersin University, Mersin, Turkey.
出版信息
Clin Appl Thromb Hemost. 2014 Mar;20(2):190-5. doi: 10.1177/1076029612456734. Epub 2012 Aug 21.
INTRODUCTION
Mean platelet volume (MPV) is an independent cardiovascular disease predictor, and characteristics of MPV in patients with diabetic nephropathy (DN) are not well known.
AIM
To determine the MPV levels in patients at different stages of DN.
PATIENTS AND METHODS
The MPV levels were investigated in healthy participants (group 1, n = 157), patients with type 2 diabetes mellitus without complication (group 2, n = 160), diabetic patients with clinical proteinuria (group 3, n = 144), and in patients with chronic kidney disease due to DN (group 4, n = 160).
FINDINGS
The MPV level was higher in all diabetic patients than that in normal participants (P < .05). The MPV values had a positive correlation with the serum creatinine and proteinuria, and a negative correlation with the glomerular filtration rate ([GFR] P < .001 for all, r values; .72, and .82, and -.92, respectively).
CONCLUSION
The MPV values were higher in diabetic groups than that in normal participants. Both GFR and proteinuria were the most powerful determinants of MPV.
引言
平均血小板体积（MPV）是心血管疾病的独立预测指标，而糖尿病肾病（DN）患者的MPV特征尚不明确。
目的
确定不同阶段DN患者的MPV水平。
患者与方法
对健康参与者（第1组，n = 157）、无并发症的2型糖尿病患者（第2组，n = 160）、有临床蛋白尿的糖尿病患者（第3组，n = 144）以及因DN导致的慢性肾脏病患者（第4组，n = 160）的MPV水平进行了研究。
研究结果
所有糖尿病患者的MPV水平均高于正常参与者（P < 0.05）。MPV值与血清肌酐和蛋白尿呈正相关，与肾小球滤过率（[GFR]，所有r值的P < 0.001；分别为0.72、0.82和 -0.92）呈负相关。
结论
糖尿病组的MPV值高于正常参与者。GFR和蛋白尿都是MPV的最有力决定因素。
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