Dis Model Mech. 2012 Sep;5(5):576-9. doi: 10.1242/dmm.010629.
Jeffrey Friedman is a molecular geneticist whose group, in 1994, reported the long-sought identity and function of leptin (Zhang et al., 1994), a key fat-derived hormone that regulates feeding behaviour and body weight. This represented a massive step forward in our understanding of obesity, which is now one of the world’s fastest-growing health problems. Here, he recalls his journey of discovery and offers his perspective on the future of obesity research.
杰弗里·弗里德曼（Jeffrey Friedman）是一位分子遗传学家，他的团队在 1994 年报告了长期以来备受关注的瘦素（leptin）的身份和功能（Zhang 等人，1994 年），瘦素是一种关键的脂肪来源激素，可调节进食行为和体重。这是我们在理解肥胖症方面迈出的一大步，肥胖症现在是世界上增长最快的健康问题之一。在这里，他回顾了自己的发现之旅，并就肥胖症研究的未来提出了自己的看法。
