Integrative Oncology Program, Oncology Service, Lin Medical Center, Clalit Health Services, Haifa and Western Galilee District, Haifa, Israel.
Breast Cancer Res Treat. 2012 Nov;136(1):1-7. doi: 10.1007/s10549-012-2211-5. Epub 2012 Aug 23.
Chemotherapy-related cognitive impairment is a phenomenon of cognitive decline that some patients experience during and after chemotherapy. The prevalence of chemotherapy-related cognitive impairment in cancer survivors ranges from 14 to 85 %. Memory loss and lack of concentration are the most frequent symptoms, often resulting in deterioration of daily functioning and a decreased quality of life. Despite ongoing research on chemotherapy-related cognitive impairment, a clear understanding of the underlying mechanisms of the neurotoxicity induced by chemotherapy and the factors that determine a patient's vulnerability are still lacking. We review current knowledge regarding the etiology of chemotherapy-related cognitive impairment, risk factors, conventional therapy, coping strategies, and potential complementary and integrative medicine treatments. Complementary and integrative medicine modalities that may improve chemotherapy-related cognitive impairment include mind-body techniques and acupuncture, as well as nutrition and herbal therapies. Studies on these modalities have not directly tested the hypothesis of modifying chemotherapy-related cognitive impairment and were done on different disorders of memory loss and lack of concentration. We recommend conducting further research on the potential role of complementary and integrative medicine modalities in the treatment and prevention of chemotherapy-related cognitive impairment.
化疗相关性认知障碍是一些患者在化疗期间和化疗后经历的认知能力下降现象。癌症幸存者中化疗相关性认知障碍的患病率为 14%至 85%。记忆力下降和注意力不集中是最常见的症状，常导致日常功能恶化和生活质量下降。尽管对化疗相关性认知障碍进行了持续的研究，但对化疗引起的神经毒性的潜在机制以及决定患者易感性的因素仍缺乏明确的认识。我们综述了目前关于化疗相关性认知障碍的病因、危险因素、常规治疗、应对策略以及潜在的补充和综合医学治疗方法的知识。可能改善化疗相关性认知障碍的补充和综合医学方法包括身心技术和针灸，以及营养和草药疗法。这些方法的研究并未直接检验改变化疗相关性认知障碍的假设，而是针对不同的记忆丧失和注意力不集中障碍进行的。我们建议进一步研究补充和综合医学方法在治疗和预防化疗相关性认知障碍中的潜在作用。
