Department of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands,
Brain Imaging Behav. 2013 Dec;7(4):453-9. doi: 10.1007/s11682-013-9250-3.
Cognitive impairment is a potential long-term side effect of adjuvant chemotherapy that can have a major impact on the quality of life of cancer survivors. There is a growing number of preclinical studies addressing this issue, thereby extending our knowledge of the mechanisms underlying chemotherapy-induced neurotoxicity. In this review, we will summarize the recent advances and important findings presented in these studies. Emerging challenges, such as the development of neuroprotective strategies, and the role of the blood-brain barrier on cognitive impairment will be described and future directions in this field of investigation will be outlined.
认知障碍是辅助化疗的一种潜在长期副作用，会对癌症幸存者的生活质量产生重大影响。越来越多的临床前研究正在解决这个问题，从而加深了我们对化疗引起的神经毒性的机制的了解。在这篇综述中，我们将总结这些研究中提出的最新进展和重要发现。新兴的挑战，如神经保护策略的发展和血脑屏障在认知障碍中的作用，将被描述，并概述该研究领域的未来方向。
