病理性人类甲状腺中的腺苷酸环化酶 - 环磷酸腺苷 - 磷酸二酯酶系统
The adenylate cyclase-cyclic AMP-phosphodiesterase system in pathological human thyroid.
作者信息
Macchia V, Mandato E, Carella C, Pisano G, Biscaglia G
出版信息
J Endocrinol Invest. 1978 Oct;1(4):337-45. doi: 10.1007/BF03350979.
The adenylate cyclase-cyclic AMP-phosphodiesterase system of human thyroid tissues adjacent to cold nodules (control), two follicular adenomas, one hyperplastic thyroid and one hyperfunctioning follicular carcinoma have been compared. In the hyperfunctional follicular carcinoma the basal adenylate cyclase is much higher than in control tissue, carcinoma adenylate cyclase does not respond to TSH and prostaglandin E1, whereas it responds normally to fluoride. In the hyperplastic, but hypofunctional thyroid the basal adenylate cyclase is higher than in normal tissue whereas the response to TSH, PGE1, and fluoride is normal. No difference between the follicular adenomas and normal thyroid stimulated and unstimulated adenylate cyclase was observed. Furthermore in various thyroid tissues no changes in the level of cyclic AMP phosphodiesterase was found. Our data indicate a greater change in the synthesis rather than in degradation of cyclic AMP in the human pathological thyroids studied.
对与冷结节相邻的人类甲状腺组织（对照）、两个滤泡性腺瘤、一个增生性甲状腺和一个功能亢进性滤泡癌的腺苷酸环化酶 - 环磷酸腺苷 - 磷酸二酯酶系统进行了比较。在功能亢进性滤泡癌中，基础腺苷酸环化酶比对照组织高得多，癌组织的腺苷酸环化酶对促甲状腺激素（TSH）和前列腺素E1无反应，而对氟化物反应正常。在增生但功能减退的甲状腺中，基础腺苷酸环化酶高于正常组织，而对TSH、PGE1和氟化物的反应正常。未观察到滤泡性腺瘤与正常甲状腺在刺激和未刺激状态下腺苷酸环化酶之间的差异。此外，在各种甲状腺组织中未发现环磷酸腺苷磷酸二酯酶水平的变化。我们的数据表明，在所研究的人类病理性甲状腺中，环磷酸腺苷合成的变化大于降解的变化。
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