Sivak Erica L, Davis Peter J
Department of Anesthesiology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Local Reg Anesth. 2010;3:35-43. doi: 10.2147/lra.s7709. Epub 2010 Jul 15.
Remifentanil is an ultrashort-acting synthetic opioid. It is metabolized by nonspecific tissue and plasma esterases. Remifentanil's metabolism is responsible for its unique pharmacokinetic profile and flat, context-sensitive half-time. Since its introduction into clinical practice, remifentanil has been used for a variety of anesthetic and analgesic applications; however, concerns regarding a potential for rapid induction of tolerance and/or induced hyperalgesia, coupled with an ultrarapid offset of effect, make the drug less than optimal for use in the pharmacologic management of pain.
瑞芬太尼是一种超短效合成阿片类药物。它由非特异性组织和血浆酯酶代谢。瑞芬太尼的代谢决定了其独特的药代动力学特征以及平稳的、与用药持续时间无关的半衰期。自引入临床实践以来，瑞芬太尼已用于多种麻醉和镇痛应用；然而，由于担心其可能迅速诱导耐受性和/或引发痛觉过敏，再加上其作用超快速消退，使得该药物在疼痛的药物管理中并非最佳选择。
