OxyMask(™)在健康志愿者中的研发与性能表现。

BACKGROUND

The OxyMask(™) is a unique, open-style, oxygen mask that was originally developed in 2005. The original mask was modified, using computational fluid dynamics numerical simulations, with the goal of allowing it to produce a wider range of FiO(2). This analysis was used to guide the modification of the mask shell and the location for the oxygen diffuser.

METHODS

The new OxyMask was attached to 10 healthy subjects and used to deliver escalating levels of oxygen (1.5, 2, 2.5, 3, 5, 10, 15, 20, 25 and 30 LPM) for 90 seconds at each level and the resulting FiO(2) was recorded (at the lips) from 5 consecutive measurements at each oxygen flow rate.

RESULTS

Mean FiO(2) was 25.4% at 1.5 LPM of oxygen, 30.1% at 2 LPM, 36.5% at 2.5 LPM, 41.8% at 3 LPM, 57.6% at 5 LPM, 74.4% at 10 LPM, and 80.1% at 15 LPM. Each FiO(2) achieved at these escalating oxygen levels was significantly greater than all the previous levels. The mean FiO(2) was 82.8 at 20 LPM, 84.2% at 25 LPM and 84.3% at 30 LPM. All of these values on average were not significantly greater than the FiO(2) achieved with 15 LPM. In a few subjects a maximum FiO(2) of 90% was reached.

CONCLUSION

The original OxyMask was successfully modified so that the second generation of the mask can provide a wide range of FiO(2), from 25% to 90%, while keeping its unique open design.

背景

OxyMask（™）是一种独特的开放式氧气面罩，最初于2005年研发。原始面罩通过计算流体动力学数值模拟进行了改进，目的是使其能够产生更广泛的氧浓度（FiO₂）范围。该分析用于指导面罩外壳的改进以及氧气扩散器的位置。

方法

将新的OxyMask连接到10名健康受试者身上，用于输送逐渐增加水平的氧气（1.5、2、2.5、3、5、10、15、20、25和30升/分钟），每个水平持续90秒，并在每个氧气流速下从连续5次测量中记录（在嘴唇处）所得的FiO₂。

结果

氧气流量为1.5升/分钟时，平均FiO₂为25.4%；2升/分钟时为30.1%；2.5升/分钟时为36.5%；3升/分钟时为41.8%；5升/分钟时为57.6%；10升/分钟时为74.4%；15升/分钟时为80.1%。在这些逐渐增加的氧气水平下达到的每个FiO₂均显著高于所有先前水平。20升/分钟时平均FiO₂为82.8%，25升/分钟时为84.2%，30升/分钟时为84.3%。所有这些值平均而言并不显著高于15升/分钟时达到的FiO₂。在少数受试者中，达到了90%的最大FiO₂。