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口服抗酸剂对口服氟康唑药代动力学的影响。

Effect of oral antacid administration on the pharmacokinetics of oral fluconazole.

作者信息

Thorpe J E, Baker N, Bromet-Petit M

机构信息

Department of Clinical Research Pfizer Central Research, Sandwich, Kent United Kingdom.

出版信息

Antimicrob Agents Chemother. 1990 Oct;34(10):2032-3. doi: 10.1128/AAC.34.10.2032.

DOI:10.1128/AAC.34.10.2032
PMID:2291673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171987/
Abstract

Absorption and elimination of fluconazole after oral administration of a 100-mg capsule were unaffected by concomitant administration of an antacid containing aluminum and magnesium hydroxides.

摘要

口服100毫克胶囊后，氟康唑的吸收和消除不受同时服用含氢氧化铝和氢氧化镁抗酸剂的影响。

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本文引用的文献

1
The influence of gastric acidity on the bio-availability of ketoconazole.胃酸对酮康唑生物利用度的影响。
J Antimicrob Chemother. 1980 Jul;6(4):552-4. doi: 10.1093/jac/6.4.552.
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Gastropathy and ketoconazole malabsorption in the acquired immunodeficiency syndrome (AIDS).获得性免疫缺陷综合征（艾滋病）中的胃病与酮康唑吸收不良
Ann Intern Med. 1988 Sep 15;109(6):471-3. doi: 10.7326/0003-4819-109-6-471.
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Gastric secretory failure in patients with the acquired immunodeficiency syndrome (AIDS).
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Gas chromatographic method for the determination of fluconazole, a novel antifungal agent, in human plasma and urine.
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Single-dose oral fluconazole in the treatment of vaginal candidosis.
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Fluconazole in the management of oropharyngeal candidosis in a predominantly HIV antibody-positive group of patients.
J Med Vet Mycol. 1988 Feb;26(1):67-71. doi: 10.1080/02681218880000081.
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The two-period cross-over clinical trial.两阶段交叉临床试验。
Br J Clin Pharmacol. 1979 Jul;8(1):7-20. doi: 10.1111/j.1365-2125.1979.tb05903.x.