Division of Translational Research, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Prog Mol Biol Transl Sci. 2012;111:139-52. doi: 10.1016/B978-0-12-398459-3.00006-X.
As drug therapy is of limited efficacy in the treatment of heart diseases related to loss of cardiomyocytes, which have very poor division potential, regenerative medicine is expected to be a new strategy to address regenerative treatment in cardiac diseases. To achieve myocardial regeneration, elucidation of the mechanism of myocardial differentiation from stem cells is essential. Myocardial differentiation from embryonic pluripotent stem cells has been investigated worldwide, and remarkable developments such as establishment of induced pluripotent stem cells and transformation of somatic cells to cardiomyocytes have recently been made, markedly changing the strategy of regenerative medicine. At the same time, the close involvement of microRNA in the maintenance, proliferation, differentiation, and reprogramming of these stem cells has been revealed. In this report, microRNA is outlined, focusing on its role in myocardial differentiation.
由于药物治疗对于治疗与心肌细胞丧失相关的心脏病的疗效有限，而心肌细胞的分裂潜能非常差，因此再生医学有望成为治疗心脏病的一种新策略。为了实现心肌再生，阐明干细胞向心肌分化的机制是至关重要的。胚胎多能干细胞向心肌的分化已在全球范围内得到研究，最近诱导多能干细胞的建立和体细胞向心肌细胞的转化等显著进展，显著改变了再生医学的策略。同时，微小 RNA 在这些干细胞的维持、增殖、分化和重编程中的密切参与也已被揭示。在本报告中，概述了微小 RNA，重点介绍了其在心肌分化中的作用。
