Department of Biochemistry and Microbiology, Damascus University, 6735 Damascus, Syria.
Metabolism. 2012 Nov;61(11):1512-7. doi: 10.1016/j.metabol.2012.07.011. Epub 2012 Aug 20.
Protein kinase CK2 was originally identified by analyzing carbohydrate metabolism. Now it is clear that life without CK2 is impossible. Moreover, CK2 activity was found elevated in rapidly proliferating cells when compared to slowly proliferating or resting cells. Proliferating cells have an elevated need for energy which is generated from an elevated carbohydrate metabolism. From early observations and the emerging role of CK2 in cellular regulation, it is not surprising that CK2 plays a role in hormonal regulation of carbohydrate metabolism as well as modulating activities of enzymes directly involved in carbohydrate storage and metabolism. The aim of the present review is to summarize the knowledge about the role of CK2 in the regulation of the carbohydrate metabolism.
蛋白激酶 CK2 最初是通过分析碳水化合物代谢而被鉴定的。现在很清楚，没有 CK2 的生命是不可能的。此外，与缓慢增殖或静止的细胞相比，在快速增殖的细胞中发现 CK2 活性升高。增殖细胞对能量的需求增加，这是由碳水化合物代谢的增加产生的。从早期的观察和 CK2 在细胞调节中的新兴作用来看，CK2 在激素调节碳水化合物代谢以及调节直接参与碳水化合物储存和代谢的酶的活性方面发挥作用也就不足为奇了。本综述的目的是总结关于 CK2 在碳水化合物代谢调节中的作用的知识。
