Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Cell Cycle. 2012 Sep 15;11(18):3384-8. doi: 10.4161/cc.21461. Epub 2012 Aug 23.
In the yeast Saccharomyces cerevisiae, small GTPase Rho1 controls polarized actin distribution and cell wall expansion in response to many different environmental and intracellular stimuli. Its activity is essential for cell survival and adaptation under various stress conditions. A recent study identified the TOR complex 1 (TORC1), a central regulator in cell growth and metabolism, as a direct target of the small GTPase. This novel crosstalk extends the signaling network of Rho1 into many TORC1-dependent processes and sheds light on how yeast cells coordinate polarized spatial expansion with mass increase.
在酵母酿酒酵母中，小分子 GTP 酶 Rho1 控制着有丝分裂肌动蛋白的分布和细胞壁的扩张，以响应许多不同的环境和细胞内刺激。其活性对各种应激条件下的细胞存活和适应至关重要。最近的一项研究确定了 TOR 复合物 1（TORC1），作为细胞生长和代谢的中央调节剂，是小分子 GTP 酶的直接靶标。这种新的串扰将 Rho1 的信号网络扩展到许多依赖 TORC1 的过程中，并揭示了酵母细胞如何协调有极性的空间扩张与质量增加。
