Virkkunen M, Linnoila M
Department of Psychiatry, Helsinki University Central Hospital, Finland.
Ann Med. 1990;22(5):327-31. doi: 10.3109/07853899009147915.
Several lines of evidence suggest that abnormal brain serotonin metabolism may occur in early onset, type 2 alcoholism in men. Low cerebrospinal fluid 5-hydroxy-indoleacetic acid concentration has been found to be associated with a history of paternal alcoholism, and abnormal oral glucose tolerance tests (tendency to low blood glucose nadir) in subjects who are prone to exhibit impulsive, aggressive behaviour under the influence of alcohol. Moreover, a low ratio of the concentrations of tryptophan and other large neutral amino acids in plasma seems to correlate with early onset alcohol abuse and violent tendencies. More knowledge is required about neurochemical changes in homogenous subgroups of alcoholics such as the putative type 2 so as to understand which of the relationships are causative and to provide treatment strategies for alcoholism and its complications.
多项证据表明，男性早发性2型酒精中毒可能存在异常的脑血清素代谢。脑脊液中5-羟吲哚乙酸浓度低与父亲有酗酒史有关，在酒精影响下容易表现出冲动、攻击行为的受试者口服葡萄糖耐量试验异常（血糖最低点偏低的倾向）。此外，血浆中色氨酸与其他大型中性氨基酸浓度的低比率似乎与早发性酒精滥用和暴力倾向相关。需要更多关于酒精中毒同质亚组（如假定的2型）神经化学变化的知识，以便了解哪些关系是因果关系，并为酒精中毒及其并发症提供治疗策略。
