Departamento de Química, Universidade Federal de São Carlos, São Carlos, SP 13565-905, Brazil.
Org Biomol Chem. 2012 Oct 14;10(38):7681-4. doi: 10.1039/c2ob26247a.
An eco-friendly synthesis of highly functionalized epoxides and their incorporation into an organocatalytic multicomponent approach are reported. For this, a modified class of diarylprolinol silyl ethers was designed to enable high catalytic activity in an environmentally benign solvent system. The one-pot procedure showed great efficiency in promoting stereoselective multicomponent transformations in a tandem, 'green' fashion. Because of its non-residual, efficient and selective character, this synthetic design shows promise for large-scale applications in both diversity and target-oriented syntheses.
本文报道了一种环保的高官能化环氧化物的合成方法，以及它们在有机催化多组分方法中的应用。为此，设计了一类改良的二芳基脯氨醇硅醚，以使其在环境友好的溶剂体系中具有高催化活性。一锅法在以“绿色”方式促进立体选择性串联多组分转化方面显示出了很高的效率。由于其非残留、高效和选择性的特点，这种合成设计有望在多样性和目标导向合成中大规模应用。
