Centre of Excellence for Research in Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil.
São Carlos Institute of Chemistry, University of São Paulo, 13563-120 São Carlos, SP, Brazil.
Molecules. 2019 Feb 11;24(3):630. doi: 10.3390/molecules24030630.
Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently involved in the synthesis of numerous bioactive products and pharmaceuticals. Because of the potential for increased efficiency and selectivity, along with the advantages of environmentally benign synthetic procedures, multicomponent reactions (MCRs) have been explored in the synthesis and ring opening of these heterocyclic units. In this review, the recent advances in MCRs involving the synthesis and applications of epoxides and aziridines to the preparation of other heterocycles are discussed emphasizing the stereoselectivity of the reactions.
小环杂环，如环氧化物和氮丙啶，存在于几种天然产物中，也是高度通用的构建块，经常参与许多生物活性产物和药物的合成。由于多组分反应（MCRs）具有提高效率和选择性的潜力，以及环境友好的合成方法的优势，因此已经探索了这些杂环单元的合成和开环中的 MCRs。在这篇综述中，讨论了涉及环氧化物和氮丙啶合成以及应用于其他杂环制备的 MCRs 的最新进展，强调了反应的立体选择性。
