新一代新生儿体外膜肺氧合双腔导管的评估
Evaluation of the new generation dual-lumen catheter for neonatal ECMO.
作者信息
Said M M, Rivera O, Mikesell G T, Rais-Bahrami K
机构信息
Department of Neonatology, Children's National Medical Center and The George Washington University School of Medicine, Washington, DC 20010, USA.
出版信息
Perfusion. 2013 Jan;28(1):26-30. doi: 10.1177/0267659112458136. Epub 2012 Aug 22.
OBJECTIVES
The purpose of this study was to compare the newly designed dual-lumen venovenous catheter (VR13, OriGen Biomedical, Austin, TX) with the current dual-lumen catheter (VV12, OriGen Biomedical).
METHODS
Five newborn lambs, 1 to 5 days old and weighing 4.2 ± 0.5 kg, were cannulated with the VV13 OriGen catheter and placed on extracorporeal membrane oxygenation (ECMO). ECMO flows were increased from 200 to 600 ml/min, with measurements taken after the changes. The experiment was then repeated using the VV12 catheter.
RESULTS
Recirculation values were equal for both catheters. The pressure drop at the reinfusion port was equal for both catheters at 200 ml/min, increasing to 275 mmHg at 500 ml/min for the VR13 vs. 240 mmHg for the VV12 catheter.
CONCLUSION
These findings indicate that the VR13 catheter resulted in levels of recirculation equal to the VV12. Based on resistance measurements, we do not recommend the use of this new catheter beyond 400 ml/min until minor design changes are made.
目的
本研究旨在比较新设计的双腔静脉导管（VR13，奥瑞金生物医学公司，德克萨斯州奥斯汀）与当前的双腔导管（VV12，奥瑞金生物医学公司）。
方法
选取5只1至5日龄、体重4.2±0.5千克的新生羔羊，用奥瑞金VV13导管进行插管，并置于体外膜肺氧合（ECMO）支持下。ECMO流量从200毫升/分钟增加到600毫升/分钟，每次流量改变后进行测量。然后使用VV12导管重复该实验。
结果
两种导管的再循环值相等。在200毫升/分钟时，两种导管在再输注端口的压降相等，在500毫升/分钟时，VR13导管的压降增加到275毫米汞柱，而VV12导管为240毫米汞柱。
结论
这些结果表明，VR13导管产生的再循环水平与VV12导管相当。基于阻力测量结果，在进行微小设计改进之前，我们不建议在流量超过400毫升/分钟时使用这种新导管。
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