Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, 1721 Speyer Lane, Redondo Beach, Los Angeles, CA 90278, USA.
Br J Psychiatry. 2012 Nov;201(5):408-9. doi: 10.1192/bjp.bp.111.107128. Epub 2012 Aug 23.
Despite accumulating evidence of structural deficits in individuals with psychopathy, especially in frontal regions, our understanding of systems-level disturbances in cortical networks remains limited. We applied novel graph theory-based methods to assess information flow and connectivity based on cortical thickness measures in 55 individuals with psychopathy and 47 normal controls. Compared with controls, the psychopathy group showed significantly altered interregional connectivity patterns. Furthermore, bilateral superior frontal cortices in the frontal network were identified as information flow control hubs in the psychopathy group in contrast to bilateral inferior frontal and medial orbitofrontal cortices as network hubs of the controls. Frontal information flow and connectivity may have a significant role in the neuropathology of psychopathy.
尽管有越来越多的证据表明精神病患者存在结构缺陷，尤其是在前额叶区域，但我们对皮质网络系统水平紊乱的理解仍然有限。我们应用新的基于图论的方法，根据 55 名精神病患者和 47 名正常对照者的皮质厚度测量值，评估信息流和连通性。与对照组相比，精神病患者组表现出明显改变的区域间连通模式。此外，在精神病患者组中，额网络的双侧额上回被确定为信息流控制枢纽，而在对照组中，双侧额下回和内侧眶额回则是网络枢纽。额叶信息流和连通性可能在精神病的神经病理学中起重要作用。
