Mitchell D G V, Avny S B, Blair R J R
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Neurocase. 2006 Jun;12(3):164-78. doi: 10.1080/13554790600611288.
An analogy is often drawn between patients with personality changes following orbitofrontal cortex lesions and individuals with developmental psychopathy. We present patient CL, who had acquired psychopathy following an orbitofrontal cortex lesion. Unlike previous studies, CL was assessed on a valid and reliable measure of psychopathy and was compared with controls and patients with developmental psychopathy on measures of instrumental (re)learning, extinction, emotional processing, and social cognition. The results provide further support for the notion that acquired and developmental forms of psychopathy are associated with dissociable neurocognitive deficits that leave each at different levels of risk for reactive and instrumental aggression.
眶额皮质损伤后出现人格改变的患者常与患有发育性精神变态的个体相类比。我们报告了患者CL，其在眶额皮质损伤后患上了精神变态。与以往研究不同的是，CL接受了一项有效且可靠的精神变态测量评估，并在工具性（再）学习、消退、情绪加工和社会认知测量方面与对照组以及患有发育性精神变态的患者进行了比较。这些结果为以下观点提供了进一步支持：后天获得性和发育性精神变态形式与可分离的神经认知缺陷相关，这些缺陷使二者在反应性和工具性攻击方面处于不同的风险水平。
