从科学到实践：巨噬细胞浸润能否作为干细胞活力的替代标志物？

Science to practice: can macrophage infiltration serve as a surrogate marker for stem cell viability?

机构信息

Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine 720 Rutland Ave, 217 Traylor, Baltimore, MD 21205, USA.

出版信息

Radiology. 2012 Sep;264(3):619-20. doi: 10.1148/radiol.12121378.

DOI:10.1148/radiol.12121378

PMID:22919033

Abstract

Following in vivo prelabeling of host macrophages with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, it was shown that their magnetic resonance (MR) imaging–visible migration into knee implants of scaffolded adipose-derived stem cells (ADSCs) undergoing apoptosis can serve as a surrogate marker of stem cell death.

摘要

在用超顺磁性氧化铁（USPIO）纳米粒子对宿主巨噬细胞进行体内预标记后，研究表明，它们的磁共振（MR）成像可见迁移到支架脂肪来源干细胞（ADSCs）凋亡的膝关节植入物中，可以作为干细胞死亡的替代标志物。