用纳米颗粒对巨噬细胞成像。
Imaging macrophages with nanoparticles.
机构信息
1] Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA [2] Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA [3] Department of Radiology, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114, USA.
1] Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA [2] Department of Radiology, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114, USA.
出版信息
Nat Mater. 2014 Feb;13(2):125-38. doi: 10.1038/nmat3780.
Nanomaterials have much to offer, not only in deciphering innate immune cell biology and tracking cells, but also in advancing personalized clinical care by providing diagnostic and prognostic information, quantifying treatment efficacy and designing better therapeutics. This Review presents different types of nanomaterial, their biological properties and their applications for imaging macrophages in human diseases, including cancer, atherosclerosis, myocardial infarction, aortic aneurysm, diabetes and other conditions. We anticipate that future needs will include the development of nanomaterials that are specific for immune cell subsets and can be used as imaging surrogates for nanotherapeutics. New in vivo imaging clinical tools for noninvasive macrophage quantification are thus ultimately expected to become relevant to predicting patients' clinical outcome, defining treatment options and monitoring responses to therapy.
纳米材料具有很大的优势，不仅可以帮助我们深入了解天然免疫细胞生物学和细胞追踪，还可以通过提供诊断和预后信息、量化治疗效果以及设计更好的治疗方法来推动个性化临床护理。本综述介绍了不同类型的纳米材料、它们的生物学特性以及它们在成像人类疾病中巨噬细胞（包括癌症、动脉粥样硬化、心肌梗死、主动脉瘤、糖尿病和其他疾病）中的应用。我们预计未来的需求将包括开发针对免疫细胞亚群的特异性纳米材料，并将其用作纳米治疗药物的成像替代物。因此，新的用于非侵入性巨噬细胞定量的体内成像临床工具最终有望与预测患者的临床结果、确定治疗方案和监测治疗反应相关。
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