Dwivedi Durgesh Kumar, Kumar Virendra, Javali Tarun, Dinda Amit K, Thulkar Sanjay, Jagannathan Naranmangalam R, Kumar Rajeev
Department of NMR, All India Institute of Medical Sciences, New Delhi, India.
Indian J Urol. 2012 Apr;28(2):243-5. doi: 10.4103/0970-1591.98487.
Current diagnostic modalities for early prostate cancer (PCa) lack sufficient sensitivity and specificity. Magnetic resonance spectroscopic imaging (MRSI) detects biochemical changes in tissues that may predate histological changes that can be diagnosed on a biopsy. Men with MRSI suggestive of malignancy but negative biopsy may thus be harboring cancer that manifests at a later date. We report the first case in our cohort of men with positive MRSI but negative initial biopsy who, 6 years after the initial MRSI, were detected to have PCa despite a "normal" prostate specific antigen (<4.0 ng/ml).
目前早期前列腺癌（PCa）的诊断方法缺乏足够的敏感性和特异性。磁共振波谱成像（MRSI）可检测组织中的生化变化，这些变化可能早于活检时可诊断的组织学变化。MRSI提示恶性但活检阴性的男性可能因此隐匿着日后会显现的癌症。我们报告了队列中首例MRSI阳性但初次活检阴性的男性病例，该患者在初次MRSI检查6年后，尽管前列腺特异性抗原“正常”（<4.0 ng/ml），仍被检测出患有前列腺癌。
