Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA.
Front Cell Infect Microbiol. 2012 Jan 11;1:25. doi: 10.3389/fcimb.2011.00025. eCollection 2011.
Burkholderia cenocepacia is an opportunistic respiratory pathogen of individuals with cystic fibrosis (CF). Some strains of B. cenocepacia are highly transmissible and resistant to almost all antibiotics. Approximately one-third of B. cenocepacia infected CF patients go on to develop fatal "cepacia syndrome." During the last two decades, substantial progress has been made with regards to evasion of host innate defense mechanisms by B. cenocepacia. Almost all strains of B. cenocepacia have the capacity to survive and replicate intracellularly in both airway epithelial cells and macrophages, which are primary sentinels of the lung and play a pivotal role in clearance of infecting bacteria. Those strains of B. cenocepacia, which express both cable pili and the associated 22 kDa adhesin are also capable of transmigrating across airway epithelium and persist in mouse models of infection. In this review, we will discuss how this type of interaction between B. cenocepacia and host may lead to persistence of bacteria as well as lung inflammation in CF patients.
洋葱伯克霍尔德菌是囊性纤维化（CF）患者的机会性呼吸道病原体。一些洋葱伯克霍尔德菌菌株具有高度传染性，几乎对所有抗生素都有耐药性。约三分之一的洋葱伯克霍尔德菌感染 CF 患者会发展为致命的“洋葱伯克霍尔德菌综合征”。在过去的二十年中，人们在逃避洋葱伯克霍尔德菌对宿主先天防御机制方面取得了重大进展。几乎所有的洋葱伯克霍尔德菌菌株都有能力在气道上皮细胞和巨噬细胞中存活和复制，而气道上皮细胞和巨噬细胞是肺部的主要哨兵，在清除感染细菌方面发挥着关键作用。那些表达菌毛和相关 22kDa 黏附素的洋葱伯克霍尔德菌菌株也能够穿过气道上皮细胞迁移，并在感染的小鼠模型中持续存在。在这篇综述中，我们将讨论这种洋葱伯克霍尔德菌与宿主之间的相互作用如何导致细菌在 CF 患者中持续存在和肺部炎症。
