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粒细胞巨噬细胞集落刺激因子(GM-CSF)治疗费尔蒂综合征的肺炎和关节炎疗效观察

Improvement of pneumonia and arthritis in Felty's syndrome by treatment with granulocyte-macrophage colony-stimulating factor (GM-CSF).

作者信息

Lübbe A S, Schwella N, Riess H, Huhn D

机构信息

Department of Internal Medicine, Free University of Berlin, Federal Republic of Germany.

出版信息

Blut. 1990 Dec;61(6):379-80. doi: 10.1007/BF01738554.

Abstract

A 63-year old man with Felty's syndrome and pneumonia of unknown origin was treated with GM-CSF. Granulocyte counts increased and arthritis-related symptoms improved under GM-CSF. Pneumonia was treated effectively with antibiotics only during or after GM-CSF application. This suggests, that antibiotic-resistant infections can be treated effectively in patients with Felty's syndrome when granulocyte counts are raised by GM-CSF.

摘要

一名患有费尔蒂综合征且病因不明的肺炎的63岁男性接受了粒细胞巨噬细胞集落刺激因子(GM-CSF)治疗。在GM-CSF治疗下,粒细胞计数增加,与关节炎相关的症状有所改善。仅在GM-CSF应用期间或之后使用抗生素有效治疗了肺炎。这表明,当通过GM-CSF提高粒细胞计数时,费尔蒂综合征患者的抗生素耐药性感染可以得到有效治疗。

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