Ngerncham Sopapan, Jirapaet Kriangsak, Suvonachai Ratanapan, Chaweerat Ranoo, Wongsiridej Pimol, Kolatat Thratip
Division of Neonatology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2012 Jul;95(7):884-9.
Neonatal hyperbilirubinemia is very common. Phototherapy has been used for decades to prevent severe hyperbilirubinemia, which can cause kernicterus.
To compare the effectiveness of two phototherapy devices in reducing plasma bilirubin and duration of phototherapy in non-severe hyperbilirubinemia.
This was an open-label randomized controlled trial. Forty healthy infants aged between 1 and 5 days with non-severe hyperbilirubinemia, but to the level requiring phototherapy, were recruited. The phototherapy unit used in the "blue-light" group was the Siriraj Phototherapy Lamp with 6 special blue fluorescent tubes. The phototherapy unit used in the "light-emitting diodes (LEDs)" group was the Bilitron 3006 with 5 super LEDs.
Twenty infants were included in each group. Demographic data and baseline clinical characteristics of infants in both groups were comparable. Median rate (25%, 75%tile) ofplasma bilirubin decreasing during phototherapy in the "blue light" was significantly higher than in the "LEDs" group [0.16 (0.09, 0.25) and 0.10 (0.02, 0.17) mg/dL/hour, respectively; p = 0.03]. Duration of phototherapy in "blue light" group was shorter than in "LEDs" group but was not statistically significant.
A locally invented phototherapy device with special blue fluorescent tubes can be more effective than the more expensive commercial super LEDs phototherapy device in decreasing plasma bilirubin.
新生儿高胆红素血症非常常见。光疗已被使用数十年以预防可导致核黄疸的严重高胆红素血症。
比较两种光疗设备在降低非严重高胆红素血症患儿血浆胆红素水平及光疗持续时间方面的有效性。
这是一项开放标签的随机对照试验。招募了40名年龄在1至5天、患有非严重高胆红素血症但达到需要光疗水平的健康婴儿。“蓝光”组使用的光疗设备是带有6根特殊蓝色荧光灯管的诗里拉吉光疗灯。“发光二极管（LED）”组使用的光疗设备是带有5个超级发光二极管的Bilitron 3006。
每组纳入20名婴儿。两组婴儿的人口统计学数据和基线临床特征具有可比性。“蓝光”组光疗期间血浆胆红素下降的中位数速率（第25百分位数，第75百分位数）显著高于“LED”组[分别为0.16（0.09，0.25）和0.10（0.02，0.17）mg/dL/小时；p = 0.03]。“蓝光”组的光疗持续时间短于“LED”组，但差异无统计学意义。
一种 locally invented 带有特殊蓝色荧光灯管的光疗设备在降低血浆胆红素方面可能比更昂贵的商用超级发光二极管光疗设备更有效。 （注：“locally invented”可能存在拼写错误，推测可能是“locally - invented”即“本地发明的” ）
