Titlić Marina, Kodzoman Katica, Loncar Dragan
University Department of Neurology, Split University Hospital Center, Split, Croatia.
Acta Clin Croat. 2012 Mar;51(1):65-9.
Hypereosinophilic syndrome is a rare disorder of the hematopoietic system. The disease is characterized by continuously high number of eosinophils (>1.5 x 10(9)/L) for more than six months. Other possible causes of hypereosinophilia, such as allergic and parasitic diseases, malignant disease, Churg-Strauss disease and infection should be eliminated. The most common manifestations of hypereosinophilic syndrome are pulmonary, skin, gastrointestinal, cardiac difficulties and neurologic lesions. Numerous neurologic lesions have been described, in particular of the central and peripheral nervous systems. Review of the literature revealed the following to have been recorded so far: mononeuritis multiplex, sensory polyneuropathy, radiculopathy, myalgia, myositis and perimyositis, neuropathy, ataxia, paraplegia, ophthalmologic abnormalities, optic neuritis, hemiplegia-hemiparesis, spasmodic quadriplegia, seizures, meningitis, cerebral infarction, organic psychosyndrome, other mental changes, stroke, temporal arteritis, leptomeningeal dissemination, memory deficits and dysarthria.
高嗜酸性粒细胞综合征是一种罕见的造血系统疾病。该疾病的特征是嗜酸性粒细胞持续高水平（>1.5×10⁹/L）超过六个月。应排除其他可能导致嗜酸性粒细胞增多的原因，如过敏性和寄生虫病、恶性疾病、变应性肉芽肿性血管炎和感染。高嗜酸性粒细胞综合征最常见的表现是肺部、皮肤、胃肠道、心脏问题和神经病变。已经描述了许多神经病变，特别是中枢和周围神经系统的病变。文献回顾显示，迄今为止已记录如下：多发性单神经炎、感觉性多发性神经病、神经根病、肌痛、肌炎和肌束膜炎、神经病、共济失调、截瘫、眼科异常、视神经炎、偏瘫-轻偏瘫、痉挛性四肢瘫、癫痫发作、脑膜炎、脑梗死、器质性精神综合征、其他精神变化、中风、颞动脉炎、软脑膜播散、记忆缺陷和构音障碍。
