Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.
Retrovirology. 2012 Aug 24;9:70. doi: 10.1186/1742-4690-9-70.
Susceptibility to HIV-1 and the clinical course after infection show a substantial heterogeneity between individuals. Part of this variability can be attributed to host genetic variation. Initial candidate gene studies have revealed interesting host factors that influence HIV infection, replication and pathogenesis. Recently, genome-wide association studies (GWAS) were utilized for unbiased searches at a genome-wide level to discover novel genetic factors and pathways involved in HIV-1 infection. This review gives an overview of findings from the GWAS performed on HIV infection, within different cohorts, with variable patient and phenotype selection. Furthermore, novel techniques and strategies in research that might contribute to the complete understanding of virus-host interactions and its role on the pathogenesis of HIV infection are discussed.
HIV-1 的易感性和感染后的临床病程在个体之间表现出很大的异质性。这种可变性的一部分可以归因于宿主遗传变异。最初的候选基因研究揭示了影响 HIV 感染、复制和发病机制的有趣宿主因素。最近，全基因组关联研究（GWAS）被用于在全基因组水平上进行无偏搜索，以发现参与 HIV-1 感染的新的遗传因素和途径。本综述概述了在不同队列中对 HIV 感染进行的 GWAS 的研究结果，这些队列在患者和表型选择上存在差异。此外，还讨论了研究中的新技术和策略，这些技术和策略可能有助于全面了解病毒-宿主相互作用及其在 HIV 感染发病机制中的作用。
