Department of Bioscience and Informatics, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuencho, Nakaku, Sakai, Osaka 599-8531, Japan.
J Org Chem. 2012 Sep 21;77(18):7844-9. doi: 10.1021/jo3008594. Epub 2012 Aug 29.
Several amino acids were tested to catalyze the transition-metal-free direct C-H arylation of unactivated benzene derivatives. Among them, proline was found to be an excellent catalyst for the cross-coupling between aryl halides and unactivated arenes. The reaction presumably involves an aryl radical anion as the intermediate based on several experiments. The reaction using this catalyst system offers an option toward establishing an environmentally benign and cost-effective route to biaryls.
几种氨基酸被测试用于催化未活化苯衍生物的过渡金属自由直接 C-H 芳基化。其中，脯氨酸被发现是芳基卤化物和未活化芳烃交叉偶联的优秀催化剂。根据几个实验，推测该反应涉及芳基自由基阴离子作为中间体。该催化剂体系的反应为建立一种环境友好且经济有效的联苯途径提供了一种选择。
