Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, and Research Institute of Oceanography, Seoul National University, NS-80, Seoul, 151-747, Korea.
Org Lett. 2012 Sep 7;14(17):4486-9. doi: 10.1021/ol3019874. Epub 2012 Aug 24.
A chemical investigation of a Korean marine sponge, Phorbas sp., yielded unprecedented sesterterpenoids phorone A (1) and isophorbasone A (2) along with ansellone B (3) and phorbasone A acetate (4). Their complete structures were elucidated by the combination of spectroscopic data and chemical manipulation. Phorone A (1) and isophorbasone A (2) have the new "phorane"(5) and "isophorbasane"(6) sesterterpenoid carbon skeletons, respectively. Ansellone B (3) and phorbasone A acetate (4) exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 LPS-activated mouse macrophage cells with IC(50) values of 4.5 and 2.8 μM, respectively.
一种韩国海洋海绵，Phorbas sp. 的化学研究产生了前所未有的甾体倍半萜 phorone A（1）和异佛尔酮基 A（2）以及ansellone B（3）和 phorbasone A 醋酸盐（4）。通过光谱数据和化学处理的组合，确定了它们的完整结构。Phorone A（1）和异佛尔酮基 A（2）分别具有新的“phorane”（5）和“isophorbasane”（6）甾体倍半萜骨架。Ansellone B（3）和 phorbasone A 醋酸盐（4）对 LPS 激活的 RAW 264.7 小鼠巨噬细胞中一氧化氮的产生具有很强的抑制活性，IC50 值分别为 4.5 和 2.8 μM。
