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来自海洋海绵及其共生生物的生物活性萜类化合物。

Bioactive Terpenes from Marine Sponges and Their Associated Organisms.

作者信息

Yuan Yuan, Lei Yu, Xu Muwu, Zhao Bingxin, Xu Shihai

机构信息

Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.

Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14260, USA.

出版信息

Mar Drugs. 2025 Feb 21;23(3):96. doi: 10.3390/md23030096.

DOI:10.3390/md23030096
PMID:40137282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11943499/
Abstract

In recent years, marine natural products have continued to serve as a pivotal resource for novel drug discovery. Globally, the number of studies focusing on Porifera has been on the rise, underscoring their considerable importance and research value. Marine sponges are prolific producers of a vast array of bioactive compounds, including terpenes, alkaloids, peptides, and numerous secondary metabolites. Over the past fifteen years, a substantial number of sponge-derived terpenes have been identified, exhibiting extensive structural diversity and notable biological activities. These terpenes have been isolated from marine sponges or their associated symbiotic microorganisms, with several demonstrating multifaceted biological activities, such as anti-inflammatory, antibacterial, cytotoxic, anticancer, and antioxidant properties. In this review, we summarize 997 novel terpene metabolites, detailing their structures, sources, and activities, from January 2009 to December 2024. The structural features and structure-activity relationship (SAR) of different types of terpenes are broadly analyzed and summarized. This systematic and comprehensive review will contribute to the summary of and speculation on the taxonomy, activity profiles, and SAR of terpenes and the development of sponge-derived terpenes as potential lead drugs.

摘要

近年来，海洋天然产物一直是新型药物发现的关键资源。在全球范围内，专注于多孔动物门的研究数量一直在增加，这凸显了它们的重要性和研究价值。海洋海绵能大量产生各种各样的生物活性化合物，包括萜类、生物碱、肽以及众多次生代谢产物。在过去的十五年里，已经鉴定出大量源自海绵的萜类，它们展现出广泛的结构多样性和显著的生物活性。这些萜类是从海洋海绵或其相关的共生微生物中分离出来的，其中一些具有多方面的生物活性，如抗炎、抗菌、细胞毒性、抗癌和抗氧化特性。在本综述中，我们总结了2009年1月至2024年12月期间的997种新型萜类代谢产物，详细介绍了它们的结构、来源和活性。对不同类型萜类的结构特征和构效关系（SAR）进行了广泛的分析和总结。这一系统而全面的综述将有助于对萜类的分类学、活性概况和构效关系进行总结和推测，并推动将源自海绵的萜类开发为潜在的先导药物。

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