Bolande R P, Mayer D C
Department of Pathology, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.
Cancer Invest. 1990;8(6):603-11. doi: 10.3109/07357909009018927.
Cell lines from 26 human cancers were studied for cytotoxicity when treated with normal pregnancy serum. Cytotoxicity manifested by cell death and cytolysis, occurred in 4 of 8 neuroblastomas studied: SK-N-SH, NGP, LAN-5, and IMR-32. In NGP and SK-N-SH, evidence is presented showing that the cytotoxicity resulted from the cell-surface binding of a natural IgM 'antibody', which sensitized the neuroblastoma cells to the lytic action of complement (C). This system may be involved in a cytolytic form of spontaneous regression of neuroblastoma.
对来自26种人类癌症的细胞系进行了研究，观察其在正常妊娠血清处理下的细胞毒性。细胞死亡和细胞溶解所表现出的细胞毒性，在8种研究的神经母细胞瘤中的4种中出现：SK-N-SH、NGP、LAN-5和IMR-32。在NGP和SK-N-SH中，有证据表明细胞毒性是由一种天然IgM“抗体”的细胞表面结合引起的，该“抗体”使神经母细胞瘤细胞对补体（C）的溶解作用敏感。该系统可能参与了神经母细胞瘤的一种细胞溶解形式的自发消退。
