Bolande R P
Department of Pathology, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.
Pediatr Pathol. 1990;10(1-2):195-206. doi: 10.3109/15513819009067107.
The cytolytic activity of normal pregnancy serum was first studied on murine cancer cells and shown to be the result of a natural IgM antibody that binds to cell surfaces and activates complement. Both the classical and alternative pathways of complement are involved. It was then shown that certain human neuroblastoma cell lines, to the exclusion of other human cancers, react to the same system. It is proposed that this system may play a role in the cytolytic form of spontaneous regression of neuroblastoma.
正常妊娠血清的细胞溶解活性首先在鼠癌细胞上进行了研究，结果表明这是一种天然IgM抗体的作用，该抗体与细胞表面结合并激活补体。补体的经典途径和替代途径均参与其中。随后发现，某些人类神经母细胞瘤细胞系（而非其他人类癌症细胞系）对同一系统有反应。有人提出，该系统可能在神经母细胞瘤的细胞溶解型自发消退中发挥作用。
